BDBM77944 US10245267, Example 381::US10709712, Example 381::US9694016, 381
SMILES Cc1cc(C(=O)Nc2ccc(C)c(c2)-c2cc(N3CCOCC3)c(=O)n(C)c2)n(C)n1
InChI Key InChIKey=MVCSKNRBGKDLBT-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 77944
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 26nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair